A-Bisabolol

A-Bisabolol (Levomenol)


Alpha-bisabolol is the primary terpene found in our #5 Full Spectrum oil. It is a sesquiterpene featured prominently in the Chamomile flower. Alpha-bisabolol (BIS) has been used for thousands of years for skin care and is an ingredient in cosmetics still today. The following is a non-exhaustive list of research of health conditions which alpha-bisabolol has been studied. We prefer to provide links to free whole research papers as much as possible. The list in alphabetical order. Most studies are heavily cited and reference, allowing you to do further research (which we highly encourage). The claims made here are solely those of the authors of the studies and not those of ItIsGoodCBD.com. Much of the research is from international sources. The quotes are directly from the papers. Spelling errors and differences exist in the original.

It Is Good! CBD makes no claims to the efficacy of a-bisabolol or our products to diagnose, treat, prevent, or cure any illness or disease. 

If you think it’s necessary, talk to your physician before including a-bisabolol to your health care regimen.


Acute Kidney Injury (AKI: Ischemia/reperfusion (I/R))

“In conclusion, (−)-α-bisabolol showed an important protective effect in both in vivo and in vitro models of kidney I/R, mainly by reducing tubular damage. This effect may be related to its antioxidant properties.”


Alzheimer’s Disease (see also: Neuroprotective)

“Overall, the anti-amyloidogenic and anti-apoptotic effect of α-bisabolol proves that it could be used as an excellent therapeutic drug to combat AD.”

“Therefore, the inhibitory activity of α-Bisabolol was evaluated in N2a cells and showed a significant reduction in AChE activity and an ability to avert Ach depletion. At the same time, α-Bisabolol protected cells from Aβ triggered apoptosis by reducing Bax and Caspase-3 and increasing Bcl-2 activity.”


Antioxident/Antibacterial

“The antibacterial activity of natural substances is an important property for bioproduct development as it minimizes preservatives, such as formaldehyde, iodopropynyl butylcarbamate, and triclosan, which induce issues such as allergies and contact dermatitis in users. ABS, a sesquiterpene alcohol, is a natural hydrophobic bioactive compound with various effects, including antioxidant and antibacterial activities.”


Arthritis

“Our findings showed that the oral administration of BIS (50 mg/kg, p.o.) and βCD/BIS (50 mg/kg, p.o.) significantly attenuated spontaneous pain-like behaviors, mechanical hyperalgesia, grip strength deficit and knee edema induced by repeated injection of CFA, reducing the joint pain and functional disability associated with arthritis. Moreover, BIS and βCD/BIS restored joint functionality and mitigated arthritic pain by inhibiting the generation of inflammatory and oxidative markers in the knee and by blocking the sensory afferent sensitivity neurons in the spinal cord.”

Breast Cancer

“The main data show that optimal dosage of BISA [bisabolol] is 10 mg/mouse rather than 3.6 mg/mouse with no adverse effects (e.g., alopecia); the number of the palpable tumor masses decreases in mice treated with 10 mg/mouse of BISA; mice, after surgical resection of the primary tumor and treatment with BISA, are free from tumor for more weeks, after the surgical treatment;….”


Cerebral ischemia

“It was observed that there was a decrease in cerebral infarct area, a prevention of memory deficits and an improvement in motor performance in mice treated with α-Bisabolol following ischaemia. In addition, the cresyl-positive cells (viable cells) were increased by α-Bisabolol treatment compared with untreated mice.”

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Chagas Disease

“It was observed that BIS [bisabolol] was able to inhibit parasite growth after 24, 48, 72 and 96 hours. Moreover, IC50 values decreased throughout the time period, which demonstrates an increasing biological effect.”


Cramps: Menstrual, pregnancy, etc.

“The anti-inflammatory and utero-relaxant effects induced by α-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place α-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.”


Crohn’s Disease (see Inflammatory Bowel Disease)

Dermatitis (Atopic Dermatitis or AD)

“BIS [bisabolol] inhibited the production of IL-4 which was released by mast cells but not T cells, and the anti-AD activity of BIS is related to the inhibition of mast-cell activation. As expected, we found that BIS reduced the infiltration and activation of mast cells in the dorsal skin…”

“Our results suggest BIS might serve as a promising therapeutic agent particularly for chronic AD patients, since it has low toxicity as classified by the United States Food and Drug Administration.”


Eczema

“Results concluded that α-Bisabolol based cream mitigated eczematous flares compared to baseline showed by a significant decrease in the affected skin surface area, improvement in the total eczema severity score outcome as well as the single area eczema severity score which includes evaluating the infiltration, lichenification and scratching lesions…”


Endometrial Cancer

"The anticancer activity of α-Bisabolol was investigated on endometrial cancer (EC) cell line on which α-Bisabolol exhibited an antitumor action by decreasing cellular viability, migration, and invasion ability of EC cells. α-Bisabolol was shown to promote apoptosis indicated by significantly increasing caspase-3 and correspondingly decreasing its direct inhibitor ;..."


Glioma

“After 24 h of treatment with 2.5-3.5 microM alpha-bisabolol, the viability of these cells was reduced by 50% with respect to untreated cells. Furthermore, the viability of normal rat glial cells was not affected by treatment with alpha-bisabolol at the same concentrations as above. Glioma cells treated with high concentration of alpha-bisabolol (10 microM) resulted in a 100% cell death.”

“…α-Bisabolol induced a cytotoxic effect on glioma cells with an inhibitory effect of 50% compared to untreated cells. The study also found that α-Bisabolol can mediate apoptosis …”


Halitosis (chronic bad breath)

“Halitosis-associated bacterium S. moorei is susceptible to the antimicrobial agents tea tree oil and alpha-bisabolol, suggesting that these compounds might be beneficial in oral healthcare products.”


Hyperpigmentation

“After 8 weeks of treatment of the α-bisabolol-containing cream, there was significant lightening effect in the pigmented skin for the majority of the subjects who tested the cream.”


Inflammatory Bowel Disease (IBD)

“Bisabolol treatment markedly prevented the villi and crypt changes, decreased submucosal edema, and thickness of muscle layer compared to the group administered only DSS. This also resulted in a significant reduction in colonic inflammation scores. SAZ also prevented the changes in colonic microarchitecture and reduced colon inflammation scores. However, α-bisabolol was more potent in reducing colon inflammation score compared to the SAZ group.”


Kidneys (See Renal injury)


Leishmaniasis

“The incubation of promastigotes of L. amazonensis with (−)α-bisabolol inhibited the parasite growth efficiently.”


Leukemia

“We and others have previously shown that the natural sesquiterpene alcohol α-BSB induces apoptotic death of a variety of neoplastic cells either in vitro or in animal models]. Notably, we have demonstrated its cytotoxicity against lymphoblastic, myeloblastic and chronic myeloid leukemia cells in preclinical studies”

“We provide here the first evidence that a-bisabolol is an effective pro-apoptotic agent in primary ALL cells at concentrations and durations that spare normal blood and bone marrow cells. … Our findings support a-bisabolol as a possible candidate for the treatment of acute leukemias…”

“It suppresses human prostate cancer and leukaemia development, arrests the cell cycle, and induces apoptosis through enhancing gap junction intercellular communication.”


Liver Cancer

“A sesquiterpene (a-Bisabolol) present in chamomile has shown apoptosis in case of carcinoma cell line HepG2 in human liver.”


Melasma

“…the integration of α-Bisabolol in a formulation intended for the treatment of melasma has shown an enhancement in the recovered melasmatic area measured by imaging techniques at the end of treatment duration compared with baseline.”


Myocardial Infarction

“The findings of the present study clearly demonstrate that α-bisabolol attenuates oxidative stress and inflammation… The underlying pharmacological and molecular mechanism of cardioprotection was attributed to its antioxidant, free radical scavenging and anti-inflammatory properties.”

Neuroprotective

“The study reported an improvement in locomotor activity, a reduction in the expression of thiol and a reinstate of the activity of mitochondrial complex-I. α-Bisabolol also increased the mRNA level of antioxidants proteins such as superoxide dismutase (SOD), catalase (CAT), and the keap1 gene product.”

Brain Visual Graphics

Pain Killer

“…this sesquiterpene was able to reduce the neuronal excitability in a concentration-dependent manner, …”

“We observed that (−)-α-bisabolol (10 mM) effects were not reversed by washing-out. In fact, VCAP values continued to decrease, reaching a plateau after 40 min of incubation.

The opposite results were observed when standard drugs were used.”

“…BIS proved to be more effective, significantly reducing nociceptive behavior in all tests including both phases of the formalin test. …BIS exhibited a significant anti-inflammatory effect (p<0.001) in the pleurisy model of inflammation, …”


Pancreatic Cancer

“We previously reported that α-bisabolol inhibits proliferation, invasiveness and motility of pancreatic cancer cells in vitro and in vivo.”

“In the present study, we demonstrated that a-bisabolol inhibited the proliferation of pancreatic cancer cells and induced their apoptosis in vitro. a-Bisabolol administration was effective against pancreatic cancer without causing any major side effects. These observations highlight a possible role for a-bisabolol as a novel antitumor drug for the treatment of pancreatic cancer.”

Parasites

“Altogether, the results demonstrate that BIS causes cell death in Trypanosoma cruzi Y strain forms, with the involvement of apoptosis and oxidative stress and enzymatic inhibition.”


Parkinson’s Disease (see also: Neuroprotective)

“The activation of glial cells is accounted for the induction of inflammation in the brain….BSB ]a-bisabolol] treatment to ROT injected rats significantly decreased (p < 0.05) the enhanced levels of these pro-inflammatory cytokines, …”


Prostate Cancer

"It suppresses human prostate cancer and leukaemia development, arrests the cell cycle, and induces apoptosis through enhancing gap junction intercellular communication..."


Renal Injury

“α-Bisabolol treatment reinstates the near normal renal architecture in rats which revealed its membrane stabilizing property…”

“The present study findings demonstrate the nephroprotective property of α-Bisabolol against DOX-induced renal injury attributing to its potent antioxidant, anti-inflammatory, anti-apoptotic, and membrane stabilizing properties. Nephrotoxicity is one of the major side effects after DOX treatment, mainly due to renal oxidative stress in cancer patients…”

“The well-documented free radical scavenging and antioxidant potential of α-Bisabolol should be correlated with the observed decrease in oxidative stress in kidney tissues. “


Skin Disorders

“α-Bisabolol was also found to enhance the effectiveness in attenuating pruritus and inflamed skin in patients with atopic dermatitis when combined with heparin in a topically applied formulation.”

“Obtained results reported a statistical significance in patients’ satisfaction in terms of improved facial texture, skin oiliness, brightness, hydrated skin, and overall appearance following the treatment.”


Stroke

“The treatment with (-)-α-bisabolol (100 and 200 mg/kg) significantly reduced the infarcted area and neurological deficits …. These data showed that (-)-α-bisabolol provides neuroprotective action probably due to its anti-inflammatory activity, although other mechanisms cannot be discarded.”


Venous Ulcers

“Furthermore, the changes in ulcer surface area were significant for ozonated oil and α-bisabolol formulation… a significant and progressive reduction of the wound surface by 34%, 59%, and 73%, after 7, 14, and 30 days of treatment, respectively.”


Wound Healing

“α-Bisabolol has been demonstrated to exert a cicatrizant effect on wounds with an ED50 of 155 µg/mL.”

“An unremarkable action of α-Bisabolol was observed on fibroblasts migration that can hasten the healing process.”

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