a-Bisabolol

a-Bisabolol

(Levomenol)

Bisabolol is a terpene many of us have seen on the ingredient list of several skincare products. Indeed, it's been used for hundreds of years as a skincare ingredient due to its potential healing properties. Because of its low-toxicity, the terpene is Generally Regarded As Safe (GRAS) by the FDA, making it an attractive, active ingredient in myriad over-the-counter cosmetics and pharmaceuticals. It is a primary terpene found in German Chamomile, making it popular in fine fragrances. It is also a primary terpene found in the oil used in our #5, with over a whopping 12,000ug/g!

The main effect for which bisabolol is known is its ability help the skin absorb better. Think of your skin as a sponge. When you pour water on a dry sponge, the water runs right off. If you pour water onto a damp sponge, it soaks right in. So, all of the other wonderful ingredients in our #5 Balm soak into the skin better due to the high content of bisabolol. Pretty cool, huh? If the CBD topical you're using doesn't have bisabolol, perhaps you should consider a different CBD topical. We know of a place that might have just what you need! (wink, wink)


Don't be fooled though, as you'll see, Bisabolol has been studied for benefits other than skin protection, including one with an "Eww" factor (we'll save that one for last).

Rotenone is a popular plant-derived compound found in many natural insecticides. It is also used to kill fish. Even though humans are a higher life form than insects and fish, you don't need to be a rocket surgeon to know that rotenone is toxic to us as well. So, what does this have to do with Bisabolol?

"ROT (Rotenone) impairs mitochondrial dysfunction being mitochondrial complex-I (MC-1) inhibitor and perturbs antioxidant-oxidant balance that contributes to the onset and development of neuroinflammation and neurodegeneration in PD (Parkinson's Disease). ...BSB (Bisabolol) treatment significantly prevented ROT-induced loss of dopaminergic neurons and fibers in the substantia nigra and striatum respectively. BSB treatment also attenuated ROT-induced oxidative stress evidenced by inhibition of MDA formation and GSH depletion as well as improvement in antioxidant enzymes, SOD and catalase."

More information about Rotenone.

Wow! Given the ease at which rotenone crosses the blood-brain barrier, those who've been exposed to high levels of rotenone may be well-served to include Bisabolol into their health care regimen. We can't give medical advice or make promises as to the efficaciousness of bisabolol, so we ask that you do your due diligence and read the link above, then read more. Remember, you can never research too much.

According to the Mayo Clinic., "Glioma is a type of tumor that occurs in the brain and spinal cord. Gliomas begin in the gluey supportive cells (glial cells) that surround nerve cells and help them function."

A 2004 study concluded that, "Glioma cells treated with a high concentration of a-bisabolol (10.0 lM) resulted in a 100% cell death. The study also revealed that the viability of normal rat glial cells (non-neuronial cells) was not affected by treatment with a-bisabolol at the same concentrations as above."

Hmm. One thing for sure, we didn't do the above study and we aren't making the claims. We're throwing it out there for you to consider, and we'll just leave it at that.

And as promised, the "Eww" factor: somewhere floating around out in this big, beautiful world is evidence suggesting that Bisabolol can rid the intestines of parasitic worms. You read that right: parasitic worms!

"The main application of x-bisabolol in the pharmaceutical sector is related to its anti-inflammatory, antispasmodic, anti-allergic, drug permeation and vermifuge [anti-worm] properties [9, 12]." Resource

While researching this topic, one will find that terpenes have been used for the elimination of parasites for a very long time. Of these, we also find "At the two highest concentrations tested (1000 and 500mug/ml), (-)alpha-bisabolol and pentamidine (control agent) achieved 100% inhibition of L. infantum promastigote. These in vitro data can be considered promising in support of the therapeutic use of (-)alpha-bisabolol preparations to treat leishmaniasis caused by L. infantum species." Resource

What??? "Promastigotes"? Believe us, you don't want to know.

We'd be remiss if we didn't mention this 2018 study from the University of California that found that parasitic worms themselves not only have an endocannabinoid system, but they excrete cannabinoid-like molecules to reduce the pain and inflammation of the host. How exciting!

"Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a "wild" new discovery by an interdisciplinary research team at the University of California, Riverside."

Ignoring the fact that that this isn't good news for someone infected with parasitic worms, what it does indicate is that cannabinoids can reduce pain and inflammation.... but you didn't hear that from us.

Of course, we can't scratch the surface on a single website of all the studies into this awesome terpene, so don't stop researching simply because you don't see a particular issue here. DIG! If bisabolol is something that you believe may help you achieve your health care goals, our "#5" tinctures and balm may be the solution you're looking for. Other studies of Bisabolol you will find in your research may include:

  • Very strong anti-inflammatory
  • Anti-microbial
  • Anti-cholinesterase (research Alzheimer's Disease)
  • Anti-biotic
  • Anti-oxidant
  • Anti-cancer properties
  • Anti-anxiety
  • Anti-depressive
  • Analgesic
  • Calmative
  • Non-allergic properties
  • Ideal for topicals
  • Discoloration fading
  • Improved suppleness of skin
  • Insecticidal
  • Anti-spasmodic
  • Anti-peptic
  • Proteolytic
  • Prevents gastric effects of Aspirin


This is by no means an exhaustive list of the studies and research of Bisabolol. Not every study determined that Bisabolol was as efficacious as other compounds. Some studies even determined that its role was minimal. So, it's up to you to make a fully-informed decision. "Copy/paste" relevant references and citations found at the end of the research articles to do deeper dives. We highly encourage it. If you find something interesting, let us know!

We here at It Is Good test and research continually. Each harvest is tested by a state-certified, third-party lab for cannabinoids, terpenes, pesticides, heavy metals, and microbials. We also test at several stages of production so that we may better understand the compounds found in a particular strain of hemp. The best way for you to stay abreast of our latest discoveries is to sign up for our monthly newsletter and our blog, where you can learn alongside us. We'll also soon have a video channel where you can watch us meet farmers, extractors, and product designers. You may also get a song or two!

Of course, none of this has been confirmed by the FDA, probably, and is therefore not intended to diagnose or treat anything. If it works for you, tell us on our Testimonial page. We love success stories!

Of course, we learn just as much from those who aren't helped by a particular product, so feel free to let us know also. It will help us select strains for our farmers to consider for next season's harvest. After that, it's totally in God's hands.